Patient 1: A 36-year-old male presents to your office being prescribed by his primary care physician (PCP) for the past 3 years an opioid analgesic medication for a work accident. He has chronic pain and is attending a pain clinic. It is determined the best course of treatment for pain is to remain on opioid medication. The patient is also being prescribed clonazepam 1mg BID for “relaxation” and panic attacks. For this patient, the long-term use of both an opioid analgesic and clonazepam requires careful evaluation to manage risks, ensure safety, and optimize treatment for chronic pain and panic disorder. Here’s a structured approach:


1. Comprehensive Assessment

  • Review Current Medications:
    • Confirm the dosage, duration, and adherence to prescribed opioid and clonazepam regimens.
    • Identify any concurrent medications or over-the-counter supplements.
  • Evaluate Indications:
    • Opioid Use: Confirm that the chronic pain condition is appropriately managed with opioids and that non-opioid alternatives have been considered.
    • Clonazepam Use: Determine if panic attacks persist and whether “relaxation” is a clinically justified reason for benzodiazepine use.
  • Assess Risks:
    • Opioid and Benzodiazepine Combination: This combination significantly increases the risk of respiratory depression, overdose, and sedation.
    • Evaluate for any signs of misuse, dependence, or substance use disorder.

2. Address Opioid Management

  • Pain Clinic Collaboration:
    • Ensure a multidisciplinary approach (e.g., physical therapy, psychological support, interventional pain treatments).
    • Consider opioid-sparing strategies where possible, such as adjunctive medications (e.g., NSAIDs, antidepressants, anticonvulsants for neuropathic pain).
  • Monitor Use:
    • Regularly assess pain levels, functionality, and quality of life using validated tools (e.g., PEG Scale: Pain, Enjoyment, General activity).
    • Perform urine drug screening periodically to ensure adherence.

3. Reassess Clonazepam Use

  • Panic Disorder Evaluation:
    • Determine if panic attacks are well-controlled and whether clonazepam is still clinically necessary.
    • If continued use is appropriate, consider tapering to the lowest effective dose.
  • Long-Term Risks:
    • Discuss the risks of benzodiazepines, including tolerance, dependence, cognitive effects, and interactions with opioids.

4. Risk Mitigation

  • Monitor for Sedation:
    • Assess for excessive sedation or respiratory depression, especially given the concurrent opioid use.
    • Avoid alcohol and other CNS depressants.
  • Consider Alternative Therapies for Panic Disorder:
    • Cognitive-behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRIs) can be effective long-term options for panic disorder and anxiety.
  • Prescribe Naloxone:
    • Educate the patient and their family on recognizing opioid overdose and using naloxone as a reversal agent.

5. Patient Education

  • Safety Emphasis:
    • Educate the patient on the risks of the opioid-benzodiazepine combination and the importance of adhering strictly to prescribed doses.
    • Discuss the signs of withdrawal, overdose, and when to seek help.
  • Empowerment:
    • Reinforce the importance of communication with all healthcare providers and transparency regarding medication use.

6. Regular Follow-Up

  • Schedule regular follow-ups to monitor:
    • Pain control and functionality.
    • Panic disorder symptoms and clonazepam effectiveness.
    • Signs of medication misuse or adverse effects.

This plan requires coordination between the prescribing PCP, pain clinic, and potentially a psychiatrist to ensure the patient receives optimal, safe, and effective care