NURS 6501 WEEK 2 CASE STUDY ANALYSIS The NURS 6501 WEEK 2 CASE STUDY ANALYSIS features a 24-year-old male patient who comes to the clinic with significant dandruff on his head and pitting of his fingernails
NURS 6501 WEEK 2 CASE STUDY ANALYSIS
The NURS 6501 WEEK 2 CASE STUDY ANALYSIS features a 24-year-old male patient who comes to the clinic with significant dandruff on his head and pitting of his fingernails. He also has morning joint soreness, which diminishes somewhat once he gets ready for work. He has tried many dandruff shampoos but has received no alleviation from his problems. A negative rheumatoid factor was found in the laboratory testing. The rate of erythrocyte sedimentation increased somewhat. The NURS 6501 WEEK 2 CASE STUDY ANALYSIS paper examines the patient’s situation and explains the immunosuppressive process and its influence on the human body.
Reasons behind the Patient’s Symptoms
The patient may have psoriatic arthritis based on the symptoms of finger pitting, scalp dandruff, and morning joint discomfort (Coates et al., 2022). Psoriatic arthritis is a chronic inflammatory disease that predominantly affects the joints and skin. They are triggered by environmental stimuli such as infection or mechanical stress. The body’s production of IL-23, a critical cytokine, is crucial in the progression of these disorders (Soomro et al., 2023). Dendritic cells and macrophages both generate IL-23. Due to impaired barrier function or changes in the microbiota, the gastrointestinal tract might be the source of IL-23. Psoriatic arthritis is characterized by enthesitis rather than synovitis, the prevailing pathological lesion in rheumatoid arthritis. Psoriatic arthritis often affects the distal interphalangeal joints, but rheumatoid arthritis does not.
Genes Associate
Researchers are now investigating the etiology of psoriatic arthritis, precisely the differential vulnerability among persons with psoriasis. The contribution is anticipated to be impacted by an intricate interaction of genetic and environmental factors. A considerable percentage, varying between 33 and 50 percent, of those who have received a diagnosis of psoriasis-related arthritis exhibit a familial pattern, wherein at least one sibling or parent has also been diagnosed with the condition (Curry et al., 2023). Psoriatic arthritis has been linked to several genes on chromosome six’s human leukocyte antigens locus. The immune function is intricately associated with this specific site. In addition, other non-HLA genes have been identified as having a potential involvement in immune function (Helliwell et al., 2023).
Immunosuppression
Immunosuppression is a physiological state in which the immune system’s capacity to effectively react to exogenous antigens, such as the surface antigens on malignant cells, is compromised. According to Xiao et al. (2023), immunosuppression may result from the destruction of immune cell effector cells or the blocking of intracellular pathways essential for identifying antigens and other immune system reactions. Continued suppression of the immune system raises the probability of acquiring cancer. Immunocompromised individuals may experience evasion of immune surveillance by possibly malignant cells that arise spontaneously or have been modified by carcinogens, which operate via mechanisms such as genotoxicity or various modes of action associated with oncogenic viruses (Schett et al., 2022). As a result, the improved capacity of these cells to survive and multiply dramatically contributes to the development of tumors. Psoriatic arthritis patients undergo immunosuppression due to immune failure during periods of active illness or the use of immunosuppressive medicines during remission, leaving them vulnerable to infections.
